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SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 125 Reviews
8.8
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Iron (as iron bisglycinate chelate†)
25 mg
139%
Top Medical Research Studies
8
Ferroportin regulates RA cell activity
Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway.
Study highlights iron's RA role
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
Most Useful Reviews
9.5
Improved health
I am alive! I have chronic anaemia and have tried various forms of iron. Oral iron often causes digestive issues, especially at high doses. Solgar is gentle and has had no side effects for me; I noticed a positive effect within three days. Remember: iron absorbs poorly with tea, coffee, and dairy. It’s best taken with vegetables, fruits, or protein. Health to you, Russians!
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9.5
Increased haemoglobin
I have suffered from low haemoglobin and ferritin for ages. After struggling with ineffective medications, I found this iron supplement and raised my haemoglobin from 100 to 125 and ferritin from 3 to 18 in 1.5 months. I will order more as the results are encouraging, and the price is reasonable.
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9.5
Rediscovered vitality
I always believed I was lazy and unmotivated until I realised I was iron deficient. After starting this supplement, my energy returned, my mood improved, and I felt like myself again. It’s essential to check your iron levels if you feel lost; this product has transformed my life.
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Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
8
Ferroportin regulates RA cell activity
Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway.
Study highlights iron's RA role
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 125 Reviews
8.8
10
Ferritin increase
After three months of taking two tablets three times daily, my ferritin level rose from 11 to 70. I have experienced no side effects, such as constipation. I've ordered another jar.
10
Hemoglobin improvement
This product truly works! My mother's haemoglobin, often between 70-90, improved to 130-140 after using the capsules. They are painless and have resolved her health issues. We've reordered, just in case her condition worsens.
10
Remarkable improvement
I bought this for my mother, who had low haemoglobin below 100. After three months of taking 1 tablet daily with folic acid and vitamin C, her haemoglobin reached 140! I couldn't believe the transformation; the drug genuinely works!
10
Encouraging results
My hair was falling out due to critically low iron levels. After various ineffective treatments, I found this product. After three months of use, my blood results showed improvement. Doctors recommend long-term iron supplements—I now suggest this permanently.
10
Normalised blood indicators
Working in a pharmacy, I've seen regular customers regain their normal ferritin levels after just one jar of this iron. I ordered it for my mum, and her results confirmed she improved within a month. Highly recommend it for anyone in need.
